Rarefaction curve online dating
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Combining capillary rarefaction with uterine artery Doppler pulsatility index increased the sensitivity and specificity of the prediction.Multivariable analysis shows that the odds of preeclampsia are increased in women with previous history of preeclampsia or chronic hypertension and in those with increased uterine artery Doppler pulsatility index, but the most powerful and independent predictor of preeclampsia was capillary rarefaction at 27–32 weeks.
It complicates 3%–7% of all pregnancies worldwide and is a major cause of maternal and neonatal mortality and morbidity while the economic cost to society is substantial.Despite the increasing research efforts in the field, the etiology and pathogenesis of this disorder remain elusive, resulting in a failure to develop specific screening, preventive, and treatment strategies.Furthermore, several cardiovascular risk factors have been identified that increase the risk of preeclampsia, such as essential hypertension, obesity, and diabetes mellitus.Women with a history of preeclampsia are also at increased risk of hypertension, stroke, and cardiovascular mortality in later life.The mechanism(s) by which these disorders are associated with preeclampsia are not fully understood, but impaired tissue perfusion and microcirculatory abnormalities, including reduction in capillary density (i.e., capillary rarefaction), have been implicated in the pathogenesis.Basal capillary density (BCD) represents the number of capillaries that are “open” or “functioning” at the time of measurement and was calculated as the mean of the 4 microscopic fields.
Maximal capillary density (MCD), which represents “structural” capillary density, was determined by venous congestion by applying a miniature BP cuff to the base of the left middle finger and inflating the cuff and maintaining the pressure at 60mm Hg for 2 minutes.We recruited a total of 322 consecutive white women with singleton pregnancies at 11–16 weeks of gestation.Participants were not chosen based on age or body mass index.The skin of the dorsum of the middle phalanx of the left hand was examined.Four microscopic fields (0.66mm These 4 fields were recorded continuously for 5 minutes to permit detection of intermittently perfused capillaries.Intra-vital capillary video-microscopy (capillaroscopy) was carried out in all patients at each of the 5 visits according to a standardized technique as described previously.